E88.0 – Disorders of plasma-protein metabolism, not elsewhere classified

ICD-10-CM 2027 diagnosis code · Metabolic disorders

Non-billable header

ICD-10-CM code E88.0
Code
E88.0 (claims format: E880)
Description
Disorders of plasma-protein metabolism, not elsewhere classified
Short description
Disorders of plasma-protein metabolism, NEC
Billable
No – use a more specific code below
Valid for
Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter
4. Endocrine, nutritional and metabolic diseases (E00-E89)
Block
E70-E88 Metabolic disorders
Parent codes
E88

Billable codes under E88.0

E88.0 is a header code and cannot be used on claims. Choose the most specific code:

Notes for E88.0

Excludes1 (not coded here):
  • monoclonal gammopathy (of undetermined significance) (D47.2)
  • polyclonal hypergammaglobulinemia (D89.0)
  • Waldenström macroglobulinemia (C88.00)
Excludes2 (not included here):
  • disorder of lipoprotein metabolism (E78.-)

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

E88 – Other and unspecified metabolic disorders

Excludes1 (not coded here):
  • histiocytosis X (chronic) (C96.6)
Use additional code:
  • codes for associated conditions

Block E70-E88

Excludes1 (not coded here):
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
Excludes2 (not included here):
  • Ehlers-Danlos syndromes (Q79.6-)

Related codes in E88

Frequently asked questions

What is ICD-10 code E88.0?

E88.0 is the ICD-10-CM code for disorders of plasma-protein metabolism, not elsewhere classified, in the block E70-E88 (Metabolic disorders).

Is E88.0 a billable code?

No. E88.0 is a header code with more specific child codes; report one of the billable codes listed above.

What category does E88.0 belong to?

It belongs to category E88 – Other and unspecified metabolic disorders.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.