E88 – Other and unspecified metabolic disorders

ICD-10-CM 2027 diagnosis code · Metabolic disorders

Non-billable header

ICD-10-CM code E88

Code: E88 (claims format: E88)
Description: Other and unspecified metabolic disorders
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 4. Endocrine, nutritional and metabolic diseases (E00-E89)
Block: E70-E88 Metabolic disorders

Billable codes under E88

E88 is a header code and cannot be used on claims. Choose the most specific code:

E88.0 – Disorders of plasma-protein metabolism, not elsewhere classifiedHeader (more codes below)
E88.1 – Lipodystrophy, not elsewhere classifiedHeader (more codes below)
E88.2 – Lipomatosis, not elsewhere classifiedBillable
E88.3 – Tumor lysis syndromeBillable
E88.4 – Mitochondrial metabolism disordersHeader (more codes below)
E88.8 – Other specified metabolic disordersHeader (more codes below)
E88.9 – Metabolic disorder, unspecifiedBillable
E88.A – Wasting disease (syndrome) due to underlying conditionBillable

Notes for E88

Excludes1 (not coded here):

histiocytosis X (chronic) (C96.6)

Use additional code:

codes for associated conditions

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

Block E70-E88

Excludes1 (not coded here):

androgen insensitivity syndrome (E34.5-)
congenital adrenal hyperplasia (E25.0)
hemolytic anemias attributable to enzyme disorders (D55.-)
Marfan syndrome (Q87.4-)
5-alpha-reductase deficiency (E29.1)

Excludes2 (not included here):

Ehlers-Danlos syndromes (Q79.6-)

Frequently asked questions

What is ICD-10 code E88?

E88 is the ICD-10-CM code for other and unspecified metabolic disorders, in the block E70-E88 (Metabolic disorders).

Is E88 a billable code?

No. E88 is a header code with more specific child codes; report one of the billable codes listed above.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.