Z16 – Resistance to antimicrobial drugs
ICD-10-CM 2027 diagnosis code · Resistance to antimicrobial drugs (Z16)
ICD-10-CM code
Z16
- Code
Z16(claims format:Z16)- Description
- Resistance to antimicrobial drugs
- Billable
- No – use a more specific code below
- Valid for
- Dates of service October 1, 2026 – September 30, 2027 (FY2027)
- Chapter
- 21. Factors influencing health status and contact with health services (Z00-Z99)
- Block
- Z16 Resistance to antimicrobial drugs (Z16)
Billable codes under Z16
Z16 is a header code and cannot be used on claims. Choose the most specific code:
- Z16.1 – Resistance to beta lactam antibioticsHeader (more codes below)
- Z16.2 – Resistance to other antibioticsHeader (more codes below)
- Z16.3 – Resistance to other antimicrobial drugsHeader (more codes below)
Notes for Z16
Excludes1 (not coded here):
Code first:
- the infection
Notes:
- The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
Frequently asked questions
What is ICD-10 code Z16?
Z16 is the ICD-10-CM code for resistance to antimicrobial drugs, in the block Z16 (Resistance to antimicrobial drugs (Z16)).
Is Z16 a billable code?
No. Z16 is a header code with more specific child codes; report one of the billable codes listed above.
Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.