Z16.1 – Resistance to beta lactam antibiotics

ICD-10-CM 2027 diagnosis code · Resistance to antimicrobial drugs (Z16)

Non-billable header

ICD-10-CM code Z16.1

Code: Z16.1 (claims format: Z161)
Description: Resistance to beta lactam antibiotics
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 21. Factors influencing health status and contact with health services (Z00-Z99)
Block: Z16 Resistance to antimicrobial drugs (Z16)
Parent codes: Z16

Billable codes under Z16.1

Z16.1 is a header code and cannot be used on claims. Choose the most specific code:

Z16.10 – Resistance to unspecified beta lactam antibioticsBillable
Z16.11 – Resistance to penicillinsBillable
Z16.12 – Extended spectrum beta lactamase (ESBL) resistanceBillable
Z16.13 – Resistance to carbapenemBillable
Z16.19 – Resistance to other specified beta lactam antibioticsBillable

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

Z16 – Resistance to antimicrobial drugs

Excludes1 (not coded here):

Methicillin resistant Staphylococcus aureus infection (A49.02)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code first:

the infection

Notes:

The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Related codes in Z16

Frequently asked questions

What is ICD-10 code Z16.1?

Z16.1 is the ICD-10-CM code for resistance to beta lactam antibiotics, in the block Z16 (Resistance to antimicrobial drugs (Z16)).

Is Z16.1 a billable code?

No. Z16.1 is a header code with more specific child codes; report one of the billable codes listed above.

What category does Z16.1 belong to?

It belongs to category Z16 – Resistance to antimicrobial drugs.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.