Z16.3 – Resistance to other antimicrobial drugs

ICD-10-CM 2027 diagnosis code · Resistance to antimicrobial drugs (Z16)

Non-billable header

ICD-10-CM code Z16.3

Code: Z16.3 (claims format: Z163)
Description: Resistance to other antimicrobial drugs
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 21. Factors influencing health status and contact with health services (Z00-Z99)
Block: Z16 Resistance to antimicrobial drugs (Z16)
Parent codes: Z16

Billable codes under Z16.3

Z16.3 is a header code and cannot be used on claims. Choose the most specific code:

Z16.30 – Resistance to unspecified antimicrobial drugsBillable
Z16.31 – Resistance to antiparasitic drug(s)Billable
Z16.32 – Resistance to antifungal drug(s)Billable
Z16.33 – Resistance to antiviral drug(s)Billable
Z16.34 – Resistance to antimycobacterial drug(s)Header (more codes below)
Z16.35 – Resistance to multiple antimicrobial drugsBillable
Z16.39 – Resistance to other specified antimicrobial drugBillable

Notes for Z16.3

Excludes1 (not coded here):

resistance to antibiotics (Z16.1-, Z16.2-)

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

Z16 – Resistance to antimicrobial drugs

Excludes1 (not coded here):

Methicillin resistant Staphylococcus aureus infection (A49.02)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code first:

the infection

Notes:

The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Related codes in Z16

Frequently asked questions

What is ICD-10 code Z16.3?

Z16.3 is the ICD-10-CM code for resistance to other antimicrobial drugs, in the block Z16 (Resistance to antimicrobial drugs (Z16)).

Is Z16.3 a billable code?

No. Z16.3 is a header code with more specific child codes; report one of the billable codes listed above.

What category does Z16.3 belong to?

It belongs to category Z16 – Resistance to antimicrobial drugs.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.