R65.11 – Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

ICD-10-CM 2027 diagnosis code · General symptoms and signs

Billable code

ICD-10-CM code R65.11
Code
R65.11 (claims format: R6511)
Description
Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
Short description
SIRS of non-infectious origin w acute organ dysfunction
Billable
Yes – valid for HIPAA-covered transactions
Valid for
Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter
18. Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)
Block
R50-R69 General symptoms and signs
Parent codes
R65 › R65.1

Notes for R65.11

Use additional code:
  • code to identify specific acute organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory failure (J96.0-)
  • critical illness myopathy (G72.81)
  • critical illness polyneuropathy (G62.81)
  • disseminated intravascular coagulopathy [DIC] (D65)
  • encephalopathy (metabolic) (septic) (G93.41)
  • hepatic failure (K72.0-)

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

R65.1 – Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Excludes1 (not coded here):
  • sepsis- code to infection
  • severe sepsis (R65.2)
Code first:
  • underlying condition, such as:
  • heatstroke (T67.0-)
  • injury and trauma (S00-T88)

Index terms for R65.11

Entries in the ICD-10-CM alphabetic index that lead to this code:

Related codes in R65.1

Frequently asked questions

What is ICD-10 code R65.11?

R65.11 is the ICD-10-CM code for systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction, in the block R50-R69 (General symptoms and signs).

Is R65.11 a billable code?

Yes. R65.11 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.

What category does R65.11 belong to?

It belongs to category R65 – Symptoms and signs specifically associated with systemic inflammation and infection.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.