R65.1 – Systemic inflammatory response syndrome (SIRS) of non-infectious origin

ICD-10-CM 2027 diagnosis code · General symptoms and signs

Non-billable header

ICD-10-CM code R65.1

Code: R65.1 (claims format: R651)
Description: Systemic inflammatory response syndrome (SIRS) of non-infectious origin
Short description: SIRS of non-infectious origin
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 18. Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)
Block: R50-R69 General symptoms and signs
Parent codes: R65

Billable codes under R65.1

R65.1 is a header code and cannot be used on claims. Choose the most specific code:

Notes for R65.1

Excludes1 (not coded here):

sepsis- code to infection
severe sepsis (R65.2)

Code first:

underlying condition, such as:
heatstroke (T67.0-)
injury and trauma (S00-T88)

Related codes in R65

R65.2 – Severe sepsisHeader

Frequently asked questions

What is ICD-10 code R65.1?

R65.1 is the ICD-10-CM code for systemic inflammatory response syndrome (SIRS) of non-infectious origin, in the block R50-R69 (General symptoms and signs).

Is R65.1 a billable code?

No. R65.1 is a header code with more specific child codes; report one of the billable codes listed above.

What category does R65.1 belong to?

It belongs to category R65 – Symptoms and signs specifically associated with systemic inflammation and infection.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.