R65.10 – Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

ICD-10-CM 2027 diagnosis code · General symptoms and signs

Billable code

ICD-10-CM code R65.10

Code: R65.10 (claims format: R6510)
Description: Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
Short description: SIRS of non-infectious origin w/o acute organ dysfunction
Billable: Yes – valid for HIPAA-covered transactions
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 18. Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)
Block: R50-R69 General symptoms and signs
Parent codes: R65 › R65.1

Notes for R65.10

Applicable to:

Systemic inflammatory response syndrome (SIRS) NOS

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

R65.1 – Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Excludes1 (not coded here):

sepsis- code to infection
severe sepsis (R65.2)

Code first:

underlying condition, such as:
heatstroke (T67.0-)
injury and trauma (S00-T88)

Index terms for R65.10

Entries in the ICD-10-CM alphabetic index that lead to this code:

Related codes in R65.1

R65.11 – Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunctionBillable

Frequently asked questions

What is ICD-10 code R65.10?

R65.10 is the ICD-10-CM code for systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction, in the block R50-R69 (General symptoms and signs).

Is R65.10 a billable code?

Yes. R65.10 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.

What category does R65.10 belong to?

It belongs to category R65 – Symptoms and signs specifically associated with systemic inflammation and infection.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.