D68.5 – Primary thrombophilia

ICD-10-CM 2027 diagnosis code · Coagulation defects, purpura and other hemorrhagic conditions

Non-billable header

ICD-10-CM code D68.5

Code: D68.5 (claims format: D685)
Description: Primary thrombophilia
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 3. Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Block: D65-D69 Coagulation defects, purpura and other hemorrhagic conditions
Parent codes: D68

Billable codes under D68.5

D68.5 is a header code and cannot be used on claims. Choose the most specific code:

D68.51 – Activated protein C resistanceBillable
D68.52 – Prothrombin gene mutationBillable
D68.59 – Other primary thrombophiliaBillable

Notes for D68.5

Applicable to:

Primary hypercoagulable states

Excludes1 (not coded here):

antiphospholipid syndrome (D68.61)
lupus anticoagulant (D68.62)
secondary activated protein C resistance (D68.69)
secondary antiphospholipid antibody syndrome (D68.69)
secondary lupus anticoagulant with hypercoagulable state (D68.69)
secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
thrombotic thrombocytopenic purpura (M31.19)

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

D68 – Other coagulation defects

Excludes1 (not coded here):

abnormal coagulation profile NOS (R79.1)

Excludes2 (not included here):

coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

Related codes in D68

D68.0 – Von Willebrand diseaseHeader
D68.1 – Hereditary factor XI deficiencyBillable
D68.2 – Hereditary deficiency of other clotting factorsBillable
D68.3 – Hemorrhagic disorder due to circulating anticoagulantsHeader
D68.4 – Acquired coagulation factor deficiencyBillable
D68.6 – Other thrombophiliaHeader
D68.8 – Other specified coagulation defectsBillable
D68.9 – Coagulation defect, unspecifiedBillable

Frequently asked questions

What is ICD-10 code D68.5?

D68.5 is the ICD-10-CM code for primary thrombophilia, in the block D65-D69 (Coagulation defects, purpura and other hemorrhagic conditions).

Is D68.5 a billable code?

No. D68.5 is a header code with more specific child codes; report one of the billable codes listed above.

What category does D68.5 belong to?

It belongs to category D68 – Other coagulation defects.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.