D68.51 – Activated protein C resistance
ICD-10-CM 2027 diagnosis code · Coagulation defects, purpura and other hemorrhagic conditions
ICD-10-CM code
D68.51
- Code
D68.51(claims format:D6851)- Description
- Activated protein C resistance
- Billable
- Yes – valid for HIPAA-covered transactions
- Valid for
- Dates of service October 1, 2026 – September 30, 2027 (FY2027)
- Chapter
- 3. Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- Block
- D65-D69 Coagulation defects, purpura and other hemorrhagic conditions
- Parent codes
- D68 › D68.5
Notes for D68.51
Applicable to:
- Factor V Leiden mutation
Notes inherited from parent codes
Instructional notes at a category or block level apply to every code below it.
D68 – Other coagulation defects
Excludes1 (not coded here):
- abnormal coagulation profile NOS (R79.1)
Excludes2 (not included here):
D68.5 – Primary thrombophilia
Applicable to:
- Primary hypercoagulable states
Excludes1 (not coded here):
- antiphospholipid syndrome (D68.61)
- lupus anticoagulant (D68.62)
- secondary activated protein C resistance (D68.69)
- secondary antiphospholipid antibody syndrome (D68.69)
- secondary lupus anticoagulant with hypercoagulable state (D68.69)
- secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
- systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
- thrombotic thrombocytopenic purpura (M31.19)
Index terms for D68.51
Entries in the ICD-10-CM alphabetic index that lead to this code:
Related codes in D68.5
Frequently asked questions
What is ICD-10 code D68.51?
D68.51 is the ICD-10-CM code for activated protein C resistance, in the block D65-D69 (Coagulation defects, purpura and other hemorrhagic conditions).
Is D68.51 a billable code?
Yes. D68.51 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.
What category does D68.51 belong to?
It belongs to category D68 – Other coagulation defects.
Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.