Z17.3 – Human epidermal growth factor 2 receptor

ICD-10-CM 2027 diagnosis code · Estrogen, and other hormones and factors receptor status (Z17)

Non-billable header

ICD-10-CM code Z17.3

Code: Z17.3 (claims format: Z173)
Description: Human epidermal growth factor 2 receptor
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 21. Factors influencing health status and contact with health services (Z00-Z99)
Block: Z17 Estrogen, and other hormones and factors receptor status (Z17)
Parent codes: Z17

Billable codes under Z17.3

Z17.3 is a header code and cannot be used on claims. Choose the most specific code:

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

Z17 – Estrogen, and other hormones and factors receptor status

Code first:

malignant neoplasm, such as:
malignant neoplasm of breast (C50.-)
malignant neoplasm of ovary (C56.-)

Notes:

Use one code, as available, for each receptor: Z17.0, Z17.1, Z17.2-, Z17.3-

Related codes in Z17

Z17.0 – Estrogen receptor positive status [ER+]Billable
Z17.1 – Estrogen receptor negative status [ER-]Billable
Z17.2 – Progesterone receptor statusHeader
Z17.4 – Combined receptor statusHeader

Frequently asked questions

What is ICD-10 code Z17.3?

Z17.3 is the ICD-10-CM code for human epidermal growth factor 2 receptor, in the block Z17 (Estrogen, and other hormones and factors receptor status (Z17)).

Is Z17.3 a billable code?

No. Z17.3 is a header code with more specific child codes; report one of the billable codes listed above.

What category does Z17.3 belong to?

It belongs to category Z17 – Estrogen, and other hormones and factors receptor status.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.