D81.82 – Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
ICD-10-CM 2027 diagnosis code · Certain disorders involving the immune mechanism
ICD-10-CM code
D81.82
- Code
D81.82(claims format:D8182)- Description
- Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
- Billable
- Yes – valid for HIPAA-covered transactions
- Valid for
- Dates of service October 1, 2026 – September 30, 2027 (FY2027)
- Chapter
- 3. Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- Block
- D80-D89 Certain disorders involving the immune mechanism
- Parent codes
- D81 › D81.8
Notes for D81.82
Applicable to:
- p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease
Notes inherited from parent codes
Instructional notes at a category or block level apply to every code below it.
D81 – Combined immunodeficiencies
Excludes1 (not coded here):
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
Block D80-D89
Includes:
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Excludes1 (not coded here):
Excludes2 (not included here):
- human immunodeficiency virus [HIV] disease (B20)
Index terms for D81.82
Entries in the ICD-10-CM alphabetic index that lead to this code:
Related codes in D81.8
Frequently asked questions
What is ICD-10 code D81.82?
D81.82 is the ICD-10-CM code for activated Phosphoinositide 3-kinase Delta Syndrome [APDS], in the block D80-D89 (Certain disorders involving the immune mechanism).
Is D81.82 a billable code?
Yes. D81.82 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.
What category does D81.82 belong to?
It belongs to category D81 – Combined immunodeficiencies.
Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.