D80 – Immunodeficiency with predominantly antibody defects
ICD-10-CM 2027 diagnosis code · Certain disorders involving the immune mechanism
ICD-10-CM code
D80
- Code
D80(claims format:D80)- Description
- Immunodeficiency with predominantly antibody defects
- Billable
- No – use a more specific code below
- Valid for
- Dates of service October 1, 2026 – September 30, 2027 (FY2027)
- Chapter
- 3. Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- Block
- D80-D89 Certain disorders involving the immune mechanism
Billable codes under D80
D80 is a header code and cannot be used on claims. Choose the most specific code:
- D80.0 – Hereditary hypogammaglobulinemiaBillable
- D80.1 – Nonfamilial hypogammaglobulinemiaBillable
- D80.2 – Selective deficiency of immunoglobulin A [IgA]Billable
- D80.3 – Selective deficiency of immunoglobulin G [IgG] subclassesBillable
- D80.4 – Selective deficiency of immunoglobulin M [IgM]Billable
- D80.5 – Immunodeficiency with increased immunoglobulin M [IgM]Billable
- D80.6 – Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemiaBillable
- D80.7 – Transient hypogammaglobulinemia of infancyBillable
- D80.8 – Other immunodeficiencies with predominantly antibody defectsBillable
- D80.9 – Immunodeficiency with predominantly antibody defects, unspecifiedBillable
Notes inherited from parent codes
Instructional notes at a category or block level apply to every code below it.
Block D80-D89
Includes:
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Excludes1 (not coded here):
Excludes2 (not included here):
- human immunodeficiency virus [HIV] disease (B20)
Frequently asked questions
What is ICD-10 code D80?
D80 is the ICD-10-CM code for immunodeficiency with predominantly antibody defects, in the block D80-D89 (Certain disorders involving the immune mechanism).
Is D80 a billable code?
No. D80 is a header code with more specific child codes; report one of the billable codes listed above.
Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.