D57.453 – Sickle-cell thalassemia beta plus with cerebral vascular involvement
ICD-10-CM 2027 diagnosis code · Hemolytic anemias
ICD-10-CM code
D57.453
- Code
D57.453(claims format:D57453)- Description
- Sickle-cell thalassemia beta plus with cerebral vascular involvement
- Short description
- Sickle-cell thalassemia beta plus with cereb vascular invl
- Billable
- Yes – valid for HIPAA-covered transactions
- Valid for
- Dates of service October 1, 2026 – September 30, 2027 (FY2027)
- Chapter
- 3. Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- Block
- D55-D59 Hemolytic anemias
- Parent codes
- D57 › D57.4 › D57.45
Notes for D57.453
Applicable to:
- HbS-beta plus with cerebral vascular involvement
- Sickle-cell beta plus with cerebral vascular involvement
Code also:
- , if applicable cerebral infarction (I63.-)
Notes inherited from parent codes
Instructional notes at a category or block level apply to every code below it.
D57 – Sickle-cell disorders
Excludes1 (not coded here):
- other hemoglobinopathies (D58.-)
Use additional code:
- code for any associated fever (R50.81)
D57.4 – Sickle-cell thalassemia
Applicable to:
- Sickle-cell beta thalassemia
- Thalassemia Hb-S disease
D57.45 – Sickle-cell thalassemia beta plus with crisis
Applicable to:
- HbS-beta plus with crisis
- Sickle-cell beta plus with crisis
Index terms for D57.453
Entries in the ICD-10-CM alphabetic index that lead to this code:
Related codes in D57.45
- D57.451 – Sickle-cell thalassemia beta plus with acute chest syndromeBillable
- D57.452 – Sickle-cell thalassemia beta plus with splenic sequestrationBillable
- D57.454 – Sickle-cell thalassemia beta plus with dactylitisBillable
- D57.458 – Sickle-cell thalassemia beta plus with crisis with other specified complicationBillable
- D57.459 – Sickle-cell thalassemia beta plus with crisis, unspecifiedBillable
Frequently asked questions
What is ICD-10 code D57.453?
D57.453 is the ICD-10-CM code for sickle-cell thalassemia beta plus with cerebral vascular involvement, in the block D55-D59 (Hemolytic anemias).
Is D57.453 a billable code?
Yes. D57.453 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.
What category does D57.453 belong to?
It belongs to category D57 – Sickle-cell disorders.
Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.