D57.4 – Sickle-cell thalassemia
ICD-10-CM 2027 diagnosis code · Hemolytic anemias
ICD-10-CM code
D57.4
- Code
D57.4(claims format:D574)- Description
- Sickle-cell thalassemia
- Billable
- No – use a more specific code below
- Valid for
- Dates of service October 1, 2026 – September 30, 2027 (FY2027)
- Chapter
- 3. Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- Block
- D55-D59 Hemolytic anemias
- Parent codes
- D57
Billable codes under D57.4
D57.4 is a header code and cannot be used on claims. Choose the most specific code:
- D57.40 – Sickle-cell thalassemia without crisisBillable
- D57.41 – Sickle-cell thalassemia, unspecified, with crisisHeader (more codes below)
- D57.42 – Sickle-cell thalassemia beta zero without crisisBillable
- D57.43 – Sickle-cell thalassemia beta zero with crisisHeader (more codes below)
- D57.44 – Sickle-cell thalassemia beta plus without crisisBillable
- D57.45 – Sickle-cell thalassemia beta plus with crisisHeader (more codes below)
Notes for D57.4
Applicable to:
- Sickle-cell beta thalassemia
- Thalassemia Hb-S disease
Notes inherited from parent codes
Instructional notes at a category or block level apply to every code below it.
D57 – Sickle-cell disorders
Excludes1 (not coded here):
- other hemoglobinopathies (D58.-)
Use additional code:
- code for any associated fever (R50.81)
Related codes in D57
Frequently asked questions
What is ICD-10 code D57.4?
D57.4 is the ICD-10-CM code for sickle-cell thalassemia, in the block D55-D59 (Hemolytic anemias).
Is D57.4 a billable code?
No. D57.4 is a header code with more specific child codes; report one of the billable codes listed above.
What category does D57.4 belong to?
It belongs to category D57 – Sickle-cell disorders.
Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.