C49 – Malignant neoplasm of other connective and soft tissue

ICD-10-CM 2027 diagnosis code · Malignant neoplasms of mesothelial and soft tissue

Non-billable header

ICD-10-CM code C49

Code: C49 (claims format: C49)
Description: Malignant neoplasm of other connective and soft tissue
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 2. Neoplasms (C00-D49)
Block: C45-C49 Malignant neoplasms of mesothelial and soft tissue

Billable codes under C49

C49 is a header code and cannot be used on claims. Choose the most specific code:

C49.0 – Malignant neoplasm of connective and soft tissue of head, face and neckBillable
C49.1 – Malignant neoplasm of connective and soft tissue of upper limb, including shoulderHeader (more codes below)
C49.2 – Malignant neoplasm of connective and soft tissue of lower limb, including hipHeader (more codes below)
C49.3 – Malignant neoplasm of connective and soft tissue of thoraxBillable
C49.4 – Malignant neoplasm of connective and soft tissue of abdomenBillable
C49.5 – Malignant neoplasm of connective and soft tissue of pelvisBillable
C49.6 – Malignant neoplasm of connective and soft tissue of trunk, unspecifiedBillable
C49.8 – Malignant neoplasm of overlapping sites of connective and soft tissueBillable
C49.9 – Malignant neoplasm of connective and soft tissue, unspecifiedBillable
C49.A – Gastrointestinal stromal tumorHeader (more codes below)

Notes for C49

Includes:

malignant neoplasm of blood vessel
malignant neoplasm of bursa
malignant neoplasm of cartilage
malignant neoplasm of fascia
malignant neoplasm of fat
malignant neoplasm of ligament, except uterine
malignant neoplasm of lymphatic vessel
malignant neoplasm of muscle
malignant neoplasm of synovia
malignant neoplasm of tendon (sheath)

Excludes1 (not coded here):

malignant neoplasm of cartilage (of):
articular (C40-C41)
larynx (C32.3)
nose (C30.0)
malignant neoplasm of connective tissue of breast (C50.-)

Excludes2 (not included here):

Kaposi's sarcoma of soft tissue (C46.1)
malignant neoplasm of heart (C38.0)
malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
malignant neoplasm of peritoneum (C48.2)
malignant neoplasm of retroperitoneum (C48.0)
malignant neoplasm of uterine ligament (C57.3)
mesothelioma (C45.-)

Frequently asked questions

What is ICD-10 code C49?

C49 is the ICD-10-CM code for malignant neoplasm of other connective and soft tissue, in the block C45-C49 (Malignant neoplasms of mesothelial and soft tissue).

Is C49 a billable code?

No. C49 is a header code with more specific child codes; report one of the billable codes listed above.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.