C49.0 – Malignant neoplasm of connective and soft tissue of head, face and neck
ICD-10-CM 2027 diagnosis code · Malignant neoplasms of mesothelial and soft tissue
ICD-10-CM code
C49.0
- Code
C49.0(claims format:C490)- Description
- Malignant neoplasm of connective and soft tissue of head, face and neck
- Short description
- Malig neoplm of conn and soft tissue of head, face and neck
- Billable
- Yes – valid for HIPAA-covered transactions
- Valid for
- Dates of service October 1, 2026 – September 30, 2027 (FY2027)
- Chapter
- 2. Neoplasms (C00-D49)
- Block
- C45-C49 Malignant neoplasms of mesothelial and soft tissue
- Parent codes
- C49
Notes for C49.0
Applicable to:
- Malignant neoplasm of connective tissue of ear
- Malignant neoplasm of connective tissue of eyelid
Excludes1 (not coded here):
- connective tissue of orbit (C69.6-)
Notes inherited from parent codes
Instructional notes at a category or block level apply to every code below it.
C49 – Malignant neoplasm of other connective and soft tissue
Includes:
- malignant neoplasm of blood vessel
- malignant neoplasm of bursa
- malignant neoplasm of cartilage
- malignant neoplasm of fascia
- malignant neoplasm of fat
- malignant neoplasm of ligament, except uterine
- malignant neoplasm of lymphatic vessel
- malignant neoplasm of muscle
- malignant neoplasm of synovia
- malignant neoplasm of tendon (sheath)
Excludes1 (not coded here):
Excludes2 (not included here):
- Kaposi's sarcoma of soft tissue (C46.1)
- malignant neoplasm of heart (C38.0)
- malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
- malignant neoplasm of peritoneum (C48.2)
- malignant neoplasm of retroperitoneum (C48.0)
- malignant neoplasm of uterine ligament (C57.3)
- mesothelioma (C45.-)
Related codes in C49
- C49.1 – Malignant neoplasm of connective and soft tissue of upper limb, including shoulderHeader
- C49.2 – Malignant neoplasm of connective and soft tissue of lower limb, including hipHeader
- C49.3 – Malignant neoplasm of connective and soft tissue of thoraxBillable
- C49.4 – Malignant neoplasm of connective and soft tissue of abdomenBillable
- C49.5 – Malignant neoplasm of connective and soft tissue of pelvisBillable
- C49.6 – Malignant neoplasm of connective and soft tissue of trunk, unspecifiedBillable
- C49.8 – Malignant neoplasm of overlapping sites of connective and soft tissueBillable
- C49.9 – Malignant neoplasm of connective and soft tissue, unspecifiedBillable
- C49.A – Gastrointestinal stromal tumorHeader
Frequently asked questions
What is ICD-10 code C49.0?
C49.0 is the ICD-10-CM code for malignant neoplasm of connective and soft tissue of head, face and neck, in the block C45-C49 (Malignant neoplasms of mesothelial and soft tissue).
Is C49.0 a billable code?
Yes. C49.0 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.
What category does C49.0 belong to?
It belongs to category C49 – Malignant neoplasm of other connective and soft tissue.
Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.