ICD-10 Code for Sepsis

The default ICD-10-CM 2027 code for sepsis (generalized) (unspecified organism) is A41.9 – Sepsis, unspecified organism. More specific codes depend on the details documented, as listed in the official index (79 codes, 59 billable).

Main code: A41.9 – Sepsis, unspecified organism
Billable: Yes

Index entries for Sepsis

with
- ectopic or molar pregnancy – O08.82
- organ dysfunction (acute) (multiple) – R65.20
  - with septic shock – R65.21
Acinetobacter baumannii – A41.54
actinomycotic – A42.7
adrenal hemorrhage syndrome (meningococcal) – A39.1
anaerobic – A41.4
Bacillus anthracis – A22.7
Brucella – A23.9 – see also Brucellosis
candidal – B37.7
Cronobacter – A41.59
cryptogenic – A41.9
due to device, implant or graft – T85.79 (header)
- arterial graft NEC – T82.7 (header)
- breast (implant) – T85.79 (header)
- catheter NEC – T85.79 (header)
  - dialysis (renal) – T82.7 (header)
    - intraperitoneal – T85.71 (header)
  - infusion NEC – T82.7 (header)
    - spinal (cranial) (epidural) (intrathecal) (spinal) (subarachnoid) (subdural) – T85.735 (header)
  - urethral indwelling – T83.511 (header)
  - urinary – T83.518 (header)
- electronic (electrode) (pulse generator) (stimulator)
  - bone – T84.7 (header)
  - cardiac – T82.7 (header)
  - nervous system – T85.738 (header)
    - brain – T85.731 (header)
    - neurostimulator generator – T85.734 (header)
    - peripheral nerve – T85.732 (header)
    - spinal cord – T85.733 (header)
  - urinary – T83.590 (header)
- fixation, internal (orthopedic) – see Complication, fixation device, infection
- gastrointestinal (bile duct) (esophagus) – T85.79 (header)
  - neurostimulator electrode (lead) – T85.732 (header)
- genital – T83.69 (header)
- heart NEC – T82.7 (header)
  - valve (prosthesis) – T82.6 (header)
    - graft – T82.7 (header)
- joint prosthesis – see Complication, joint prosthesis, infection
- ocular (corneal graft) (orbital implant) – T85.79 (header)
- orthopedic NEC – T84.7 (header)
  - fixation device, internal – see Complication, fixation device, infection
- specified NEC – T85.79 (header)
- vascular – T82.7 (header)
- ventricular intracranial (communicating) – T85.730 (header)
during labor – O75.3
Enterococcus – A41.81
Erysipelothrix (rhusiopathiae) (erysipeloid) – A26.7
Escherichia coli (E. coli) – A41.51
extraintestinal yersiniosis – A28.2
following
- abortion (subsequent episode) – O08.0
  - current episode – see Abortion
- ectopic or molar pregnancy – O08.82
- immunization – T88.0 (header)
- infusion, therapeutic injection or transfusion NEC – T80.29 (header)
- obstetrical procedure – O86.04
gangrenous – A41.9
gonococcal – A54.86
Gram-negative (organism) – A41.50
- anaerobic – A41.4
Haemophilus influenzae – A41.3
herpesviral – B00.7
intra-abdominal – K65.1
intraocular – see Endophthalmitis, purulent
Listeria monocytogenes – A32.7
localized - code to specific localized infection
- in operation wound – T81.49 (header)
- skin – see Abscess
malleus – A24.0
melioidosis – A24.1
meningeal – see Meningitis
meningococcal – A39.4
- acute – A39.2
- chronic – A39.3
MRSA (Methicillin resistant Staphylococcus aureus) – A41.02
MSSA (Methicillin susceptible Staphylococcus aureus) – A41.01
newborn – P36.9
- due to
  - anaerobes NEC – P36.5
  - Escherichia coli – P36.4
  - Staphylococcus – P36.30
    - aureus – P36.2
    - specified NEC – P36.39
  - Streptococcus – P36.10
    - group B – P36.0
    - specified NEC – P36.19
- specified NEC – P36.8
other gram-negative – A41.59
Pasteurella multocida – A28.0
pelvic, puerperal, postpartum, childbirth – O85
postprocedural – T81.44 (header)
pneumococcal – A40.3
Pseudomonas (pseudomonas aeruginosa) – A41.52
puerperal, postpartum, childbirth (pelvic) – O85
Salmonella (arizonae) (cholerae-suis) (enteritidis) (typhimurium) – A02.1
Serratia – A41.53
severe – R65.20
- with septic shock – R65.21
skin, localized – see Abscess
Shigella – A03.9 – see also Dysentery, bacillary
specified organism NEC – A41.89
Staphylococcus, staphylococcal – A41.2
- aureus (methicillin susceptible) (MSSA) – A41.01
  - methicillin resistant (MRSA) – A41.02
- coagulase-negative – A41.1
- specified NEC – A41.1
Streptococcus, streptococcal – A40.9
- agalactiae – A40.1
- group
  - A – A40.0
  - B – A40.1
  - D – A41.81
- neonatal – P36.10
  - group B – P36.0
  - specified NEC – P36.19
- pneumoniae – A40.3
- pyogenes – A40.0
- specified NEC – A40.8
tracheostomy stoma – J95.02
tularemic – A21.7
umbilical, umbilical cord (newborn) – see Sepsis, newborn
Yersinia pestis – A20.7

How to choose the right code

Start with the main term, then pick the indented subterm that matches the documentation (type, cause, site, laterality, episode of care). Always confirm the code in the tabular list: follow its Excludes1/Excludes2, “code first” and “use additional code” notes, and add a 7th character where required.

Source: CDC/NCHS ICD-10-CM FY2027 alphabetic index.