Z16.22 – Resistance to vancomycin related antibiotics

ICD-10-CM 2027 diagnosis code · Resistance to antimicrobial drugs (Z16)

Billable code

ICD-10-CM code Z16.22

Code: Z16.22 (claims format: Z1622)
Description: Resistance to vancomycin related antibiotics
Billable: Yes – valid for HIPAA-covered transactions
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 21. Factors influencing health status and contact with health services (Z00-Z99)
Block: Z16 Resistance to antimicrobial drugs (Z16)
Parent codes: Z16 › Z16.2

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

Z16 – Resistance to antimicrobial drugs

Excludes1 (not coded here):

Methicillin resistant Staphylococcus aureus infection (A49.02)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code first:

the infection

Notes:

The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Index terms for Z16.22

Entries in the ICD-10-CM alphabetic index that lead to this code:

Resistance, resistant, organism, to, drug, vancomycin, related antibiotics

Related codes in Z16.2

Z16.20 – Resistance to unspecified antibioticBillable
Z16.21 – Resistance to vancomycinBillable
Z16.23 – Resistance to quinolones and fluoroquinolonesBillable
Z16.24 – Resistance to multiple antibioticsBillable
Z16.29 – Resistance to other single specified antibioticBillable

Frequently asked questions

What is ICD-10 code Z16.22?

Z16.22 is the ICD-10-CM code for resistance to vancomycin related antibiotics, in the block Z16 (Resistance to antimicrobial drugs (Z16)).

Is Z16.22 a billable code?

Yes. Z16.22 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.

What category does Z16.22 belong to?

It belongs to category Z16 – Resistance to antimicrobial drugs.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.