K52.21 – Food protein-induced enterocolitis syndrome

ICD-10-CM 2027 diagnosis code · Noninfective enteritis and colitis

Billable code

ICD-10-CM code K52.21

Code: K52.21 (claims format: K5221)
Description: Food protein-induced enterocolitis syndrome
Billable: Yes – valid for HIPAA-covered transactions
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 11. Diseases of the digestive system (K00-K95)
Block: K50-K52 Noninfective enteritis and colitis
Parent codes: K52 › K52.2

Notes for K52.21

Applicable to:

FPIES

Use additional code:

code for hypovolemic shock, if present (R57.1)

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

K52.2 – Allergic and dietetic gastroenteritis and colitis

Applicable to:

Food hypersensitivity gastroenteritis or colitis

Excludes2 (not included here):

allergic eosinophilic colitis (K52.82)
allergic eosinophilic esophagitis (K20.0)
allergic eosinophilic gastritis (K52.81)
allergic eosinophilic gastroenteritis (K52.81)

Use additional code:

code to identify type of food allergy (Z91.01-, Z91.02-)

Block K50-K52

Includes:

noninfective inflammatory bowel disease

Excludes1 (not coded here):

irritable bowel syndrome (K58.-)
megacolon (K59.3-)

Index terms for K52.21

Entries in the ICD-10-CM alphabetic index that lead to this code:

Related codes in K52.2

Frequently asked questions

What is ICD-10 code K52.21?

K52.21 is the ICD-10-CM code for food protein-induced enterocolitis syndrome, in the block K50-K52 (Noninfective enteritis and colitis).

Is K52.21 a billable code?

Yes. K52.21 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.

What category does K52.21 belong to?

It belongs to category K52 – Other and unspecified noninfective gastroenteritis and colitis.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.