D89.3 – Immune reconstitution syndrome

ICD-10-CM 2027 diagnosis code · Certain disorders involving the immune mechanism

Billable code

ICD-10-CM code D89.3

Code: D89.3 (claims format: D893)
Description: Immune reconstitution syndrome
Billable: Yes – valid for HIPAA-covered transactions
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 3. Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Block: D80-D89 Certain disorders involving the immune mechanism
Parent codes: D89

Notes for D89.3

Applicable to:

Immune reconstitution inflammatory syndrome [IRIS]

Use additional code:

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

D89 – Other disorders involving the immune mechanism, not elsewhere classified

Excludes1 (not coded here):

hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes2 (not included here):

transplant failure and rejection (T86.-)

Block D80-D89

Includes:

defects in the complement system
immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
sarcoidosis

Excludes1 (not coded here):

autoimmune disease (systemic) NOS (M35.9)
functional disorders of polymorphonuclear neutrophils (D71-)

Excludes2 (not included here):

human immunodeficiency virus [HIV] disease (B20)

Index terms for D89.3

Entries in the ICD-10-CM alphabetic index that lead to this code:

Related codes in D89

Frequently asked questions

What is ICD-10 code D89.3?

D89.3 is the ICD-10-CM code for immune reconstitution syndrome, in the block D80-D89 (Certain disorders involving the immune mechanism).

Is D89.3 a billable code?

Yes. D89.3 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.

What category does D89.3 belong to?

It belongs to category D89 – Other disorders involving the immune mechanism, not elsewhere classified.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.