ICD-10 Code for Syphilis

The default ICD-10-CM 2027 code for syphilis, syphilitic (acquired) is A53.9 – Syphilis, unspecified. More specific codes depend on the details documented, as listed in the official index (79 codes, 79 billable).

Main code: A53.9 – Syphilis, unspecified
Billable: Yes

Index entries for Syphilis

abdomen (late) – A52.79
acoustic nerve – A52.15
adenopathy (secondary) – A51.49
adrenal (gland) (with cortical hypofunction) – A52.79
age under 2 years NOS – see also Syphilis, congenital, early
- acquired – A51.9
alopecia (secondary) – A51.32
anemia (late) – A52.79 – D63.8 [manifestation]
aneurysm (aorta) (ruptured) – A52.01
- central nervous system – A52.05
- congenital – A50.54 – I79.0 [manifestation]
anus (late) – A52.74
- primary – A51.1
- secondary – A51.39
aorta (arch) (abdominal) (thoracic) – A52.02
- aneurysm – A52.01
aortic (insufficiency) (regurgitation) (stenosis) – A52.03
- aneurysm – A52.01
arachnoid (adhesive) (cerebral) (spinal) – A52.13
asymptomatic – see Syphilis, latent
ataxia (locomotor) – A52.11
atrophoderma maculatum – A51.39
auricular fibrillation – A52.06
bladder (late) – A52.76
bone – A52.77
- secondary – A51.46
brain – A52.17
breast (late) – A52.79
bronchus (late) – A52.72
bubo (primary) – A51.0
bulbar palsy – A52.19
bursa (late) – A52.78
cardiac decompensation – A52.06
cardiovascular – A52.00
central nervous system (late) (recurrent) (relapse) (tertiary) – A52.3
- with
  - ataxia – A52.11
  - general paralysis – A52.17
    - juvenile – A50.45
  - paresis (general) – A52.17
    - juvenile – A50.45
  - tabes (dorsalis) – A52.11
    - juvenile – A50.45
  - taboparesis – A52.17
    - juvenile – A50.45
- aneurysm – A52.05
- congenital – A50.40
- juvenile – A50.40
- remission in (sustained) – A52.3
- serology doubtful, negative, or positive – A52.3
- specified nature or site NEC – A52.19
- vascular – A52.05
cerebral – A52.17
- meningovascular – A52.13
- nerves (multiple palsies) – A52.15
- sclerosis – A52.17
- thrombosis – A52.05
cerebrospinal (tabetic type) – A52.12
cerebrovascular – A52.05
cervix (late) – A52.76
chancre (multiple) – A51.0
- extragenital – A51.2
- Rollet's – A51.0
Charcot's joint – A52.16
chorioretinitis – A51.43
- congenital – A50.01
- late – A52.71
- prenatal – A50.01
choroiditis – see Syphilitic chorioretinitis
choroidoretinitis – see Syphilitic chorioretinitis
ciliary body (secondary) – A51.43
- late – A52.71
colon (late) – A52.74
combined spinal sclerosis – A52.11
condyloma (latum) – A51.31
congenital – A50.9
- with
  - paresis (general) – A50.45
  - tabes (dorsalis) – A50.45
  - taboparesis – A50.45
- chorioretinitis, choroiditis – A50.01 – H32 [manifestation]
- early, or less than 2 years after birth NEC – A50.2
  - with manifestations – see Syphilis, congenital, early, symptomatic
  - latent (without manifestations) – A50.1
    - negative spinal fluid test – A50.1
    - serology positive – A50.1
  - symptomatic – A50.09
    - cutaneous – A50.06
    - mucocutaneous – A50.07
    - oculopathy – A50.01
    - osteochondropathy – A50.02
    - pharyngitis – A50.03
    - pneumonia – A50.04
    - rhinitis – A50.05
    - visceral – A50.08
- interstitial keratitis – A50.31
- juvenile neurosyphilis – A50.45
- late, or 2 years or more after birth NEC – A50.7
  - chorioretinitis, choroiditis – A50.32
  - interstitial keratitis – A50.31
  - juvenile neurosyphilis – A50.45
  - latent (without manifestations) – A50.6
    - negative spinal fluid test – A50.6
    - serology positive – A50.6
  - symptomatic or with manifestations NEC – A50.59
    - arthropathy – A50.55
    - cardiovascular – A50.54
    - Clutton's joints – A50.51
    - Hutchinson's teeth – A50.52
    - Hutchinson's triad – A50.53
    - osteochondropathy – A50.56
    - saddle nose – A50.57
conjugal – A53.9
- tabes – A52.11
conjunctiva (late) – A52.71
contact – Z20.2
cord bladder – A52.19
cornea, late – A52.71
coronary (artery) (sclerosis) – A52.06
coryza, congenital – A50.05
cranial nerve – A52.15
- multiple palsies – A52.15
cutaneous – see Syphilis, skin
dacryocystitis (late) – A52.71
degeneration, spinal cord – A52.12
dementia paralytica – A52.17
- juvenilis – A50.45
destruction of bone – A52.77
dilatation, aorta – A52.01
due to blood transfusion – A53.9
dura mater – A52.13
ear – A52.79
- inner – A52.79
  - nerve (eighth) – A52.15
  - neurorecurrence – A52.15
early – A51.9
- cardiovascular – A52.00
- central nervous system – A52.3
- latent (without manifestations) (less than 2 years after infection) – A51.5
  - negative spinal fluid test – A51.5
  - serological relapse after treatment – A51.5
  - serology positive – A51.5
- relapse (treated, untreated) – A51.9
- skin – A51.39
- symptomatic – A51.9
  - extragenital chancre – A51.2
  - primary, except extragenital chancre – A51.0
  - secondary – A51.39 – see also Syphilis, secondary
    - relapse (treated, untreated) – A51.49
- ulcer – A51.39
eighth nerve (neuritis) – A52.15
endemic – A65
endocarditis – A52.03
- aortic – A52.03
- pulmonary – A52.03
epididymis (late) – A52.76
epiglottis (late) – A52.73
epiphysitis (congenital) (early) – A50.02
episcleritis (late) – A52.71
esophagus – A52.79
eustachian tube – A52.73
exposure to – Z20.2
eye – A52.71
eyelid (late) (with gumma) – A52.71
fallopian tube (late) – A52.76
fracture – A52.77
gallbladder (late) – A52.74
gastric (polyposis) (late) – A52.74
general – A53.9
- paralysis – A52.17
  - juvenile – A50.45
genital (primary) – A51.0
glaucoma – A52.71
gumma NEC – A52.79
- cardiovascular system – A52.00
- central nervous system – A52.3
- congenital – A50.59
heart (block) (decompensation) (disease) (failure) – A52.06 – I52 [manifestation]
- valve NEC – A52.03
hemianesthesia – A52.19
hemianopsia – A52.71
hemiparesis – A52.17
hemiplegia – A52.17
hepatic artery – A52.09
hepatis – A52.74
hepatomegaly, congenital – A50.08
hereditaria tarda – see Syphilis, congenital, late
hereditary – see Syphilis, congenital
Hutchinson's teeth – A50.52
hyalitis – A52.71
inactive – see Syphilis, latent
infantum – see Syphilis, congenital
inherited – see Syphilis, congenital
internal ear – A52.79
intestine (late) – A52.74
iris, iritis (secondary) – A51.43
- late – A52.71
joint (late) – A52.77
keratitis (congenital) (interstitial) (late) – A50.31
kidney (late) – A52.75
lacrimal passages (late) – A52.71
larynx (late) – A52.73
late – A52.9
- cardiovascular – A52.00
- central nervous system – A52.3
- kidney – A52.75
- latent or 2 years or more after infection (without manifestations) – A52.8
  - negative spinal fluid test – A52.8
  - serology positive – A52.8
- paresis – A52.17
- specified site NEC – A52.79
- symptomatic or with manifestations – A52.79
- tabes – A52.11
latent – A53.0
- with signs or symptoms - code by site and stage under Syphilis
- central nervous system – A52.2
- date of infection unspecified – A53.0
- early, or less than 2 years after infection – A51.5
- follow-up of latent syphilis – A53.0
  - date of infection unspecified – A53.0
  - late, or 2 years or more after infection – A52.8
- late, or 2 years or more after infection – A52.8
- positive serology (only finding) – A53.0
  - date of infection unspecified – A53.0
  - early, or less than 2 years after infection – A51.5
  - late, or 2 years or more after infection – A52.8
lens (late) – A52.71
leukoderma – A51.39
- late – A52.79
lienitis – A52.79
lip – A51.39
- chancre (primary) – A51.2
- late – A52.79
Lissauer's paralysis – A52.17
liver – A52.74
locomotor ataxia – A52.11
lung – A52.72
lymph gland (early) (secondary) – A51.49
- late – A52.79
lymphadenitis (secondary) – A51.49
macular atrophy of skin – A51.39
- striated – A52.79
mediastinum (late) – A52.73
meninges (adhesive) (brain) (spinal cord) – A52.13
meningitis – A52.13
- acute (secondary) – A51.41
- congenital – A50.41
meningoencephalitis – A52.14
meningovascular – A52.13
- congenital – A50.41
mesarteritis – A52.09
- brain – A52.04
middle ear – A52.77
mitral stenosis – A52.03
monoplegia – A52.17
mouth (secondary) – A51.39
- late – A52.79
mucocutaneous (secondary) – A51.39
- late – A52.79
mucous
- membrane (secondary) – A51.39
  - late – A52.79
- patches – A51.39
  - congenital – A50.07
mulberry molars – A50.52
muscle – A52.78
myocardium – A52.06
nasal sinus (late) – A52.73
neonatorum – see Syphilis, congenital
nephrotic syndrome (secondary) – A51.44
nerve palsy (any cranial nerve) – A52.15
- multiple – A52.15
nervous system, central – A52.3
neuritis – A52.15
- acoustic – A52.15
neurorecidive of retina – A52.19
neuroretinitis – A52.19
newborn – see Syphilis, congenital
nodular superficial (late) – A52.79
nonvenereal – A65
nose (late) – A52.73
- saddle back deformity – A50.57
occlusive arterial disease – A52.09
oculopathy – A52.71
ophthalmic (late) – A52.71
optic nerve (atrophy) (neuritis) (papilla) – A52.15
orbit (late) – A52.71
organic – A53.9
osseous (late) – A52.77
osteochondritis (congenital) (early) – A50.02 – M90.80 [manifestation]
osteoporosis – A52.77
ovary (late) – A52.76
oviduct (late) – A52.76
palate (late) – A52.79
pancreas (late) – A52.74
paralysis – A52.17
- general – A52.17
  - juvenile – A50.45
paresis (general) – A52.17
- juvenile – A50.45
paresthesia – A52.19
Parkinson's disease or syndrome – A52.19
paroxysmal tachycardia – A52.06
pemphigus (congenital) – A50.06
penis (chancre) – A51.0
- late – A52.76
pericardium – A52.06
perichondritis, larynx (late) – A52.73
periosteum (late) – A52.77
- congenital (early) – A50.02 – M90.80 [manifestation]
- early (secondary) – A51.46
peripheral nerve – A52.79
petrous bone (late) – A52.77
pharynx (late) – A52.73
- secondary – A51.39
pituitary (gland) – A52.79
pleura (late) – A52.73
pneumonia, white – A50.04
pontine lesion – A52.17
portal vein – A52.09
primary – A51.0
- anal – A51.1
- and secondary – see Syphilis, secondary
- central nervous system – A52.3
- extragenital chancre NEC – A51.2
- fingers – A51.2
- genital – A51.0
- lip – A51.2
- specified site NEC – A51.2
- tonsils – A51.2
prostate (late) – A52.76
ptosis (eyelid) – A52.71
pulmonary (late) – A52.72
- artery – A52.09
pyelonephritis (late) – A52.75
recently acquired, symptomatic – A51.9
rectum (late) – A52.74
respiratory tract (late) – A52.73
retina, late – A52.71
retrobulbar neuritis – A52.15
salpingitis – A52.76
sclera (late) – A52.71
sclerosis
- cerebral – A52.17
- coronary – A52.06
- multiple – A52.11
scotoma (central) – A52.71
scrotum (late) – A52.76
secondary (and primary) – A51.49
- adenopathy – A51.49
- anus – A51.39
- bone – A51.46
- chorioretinitis, choroiditis – A51.43
- hepatitis – A51.45
- liver – A51.45
- lymphadenitis – A51.49
- meningitis (acute) – A51.41
- mouth – A51.39
- mucous membranes – A51.39
- periosteum, periostitis – A51.46
- pharynx – A51.39
- relapse (treated, untreated) – A51.49
- skin – A51.39
- specified form NEC – A51.49
- tonsil – A51.39
- ulcer – A51.39
- viscera NEC – A51.49
- vulva – A51.39
seminal vesicle (late) – A52.76
seronegative with signs or symptoms - code by site and stage under Syphilis
seropositive
- with signs or symptoms - code by site and stage under Syphilis
- follow-up of latent syphilis – see Syphilis, latent
- only finding – see Syphilis, latent
seventh nerve (paralysis) – A52.15
sinus, sinusitis (late) – A52.73
skeletal system – A52.77
skin (with ulceration) (early) (secondary) – A51.39
- late or tertiary – A52.79
small intestine – A52.74
spastic spinal paralysis – A52.17
spermatic cord (late) – A52.76
spinal (cord) – A52.12
spleen – A52.79
splenomegaly – A52.79
spondylitis – A52.77
staphyloma – A52.71
stigmata (congenital) – A50.59
stomach – A52.74
synovium – A52.78
tabes dorsalis (late) – A52.11
- juvenile – A50.45
tabetic type – A52.11
- juvenile – A50.45
taboparesis – A52.17
- juvenile – A50.45
tachycardia – A52.06
tendon (late) – A52.78
tertiary – A52.9
- with symptoms NEC – A52.79
- cardiovascular – A52.00
- central nervous system – A52.3
- multiple NEC – A52.79
- specified site NEC – A52.79
testis – A52.76
thorax – A52.73
throat – A52.73
thymus (gland) (late) – A52.79
thyroid (late) – A52.79
tongue (late) – A52.79
tonsil (lingual) (late) – A52.73
- primary – A51.2
- secondary – A51.39
trachea (late) – A52.73
tunica vaginalis (late) – A52.76
ulcer (any site) (early) (secondary) – A51.39
- late – A52.79
- perforating – A52.79
  - foot – A52.11
urethra (late) – A52.76
urogenital (late) – A52.76
uterus (late) – A52.76
uveal tract (secondary) – A51.43
- late – A52.71
uveitis (secondary) – A51.43
- late – A52.71
uvula (late) (perforated) – A52.79
vagina – A51.0
- late – A52.76
valvulitis NEC – A52.03
vascular – A52.00
- brain (cerebral) – A52.05
ventriculi – A52.74
vesicae urinariae (late) – A52.76
viscera (abdominal) (late) – A52.74
- secondary – A51.49
vitreous (opacities) (late) – A52.71
- hemorrhage – A52.71
vulva – A51.0
- late – A52.76
- secondary – A51.39

How to choose the right code

Start with the main term, then pick the indented subterm that matches the documentation (type, cause, site, laterality, episode of care). Always confirm the code in the tabular list: follow its Excludes1/Excludes2, “code first” and “use additional code” notes, and add a 7th character where required.

Source: CDC/NCHS ICD-10-CM FY2027 alphabetic index.