C5278 – Application of low cost skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (list separately in addition to code for primary procedure)

HCPCS Level II code · C codes: Outpatient PPS (Hospital Outpatient)

Discontinued December 31, 2025 Special coverage instructions apply

HCPCS codeC5278
Long description
Application of low cost skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (list separately in addition to code for primary procedure)
Short description
Low cost skin substitute app
Pricing indicator
53 Statute
Medicare coverage
D Special coverage instructions apply
BETOS category
P5A Ambulatory procedures - skin
Added
January 1, 2014
Last change
January 1, 2026 – No change
Termination date
December 31, 2025

Frequently asked questions

What is HCPCS code C5278?

C5278 is a HCPCS Level II code for application of low cost skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (list separately in addition to code for primary procedure). It was discontinued on December 31, 2025.

Does Medicare cover C5278?

The HCPCS file lists coverage code D: Special coverage instructions apply. Coverage and payment also depend on local coverage determinations and the patient’s plan.

Nearby C codes

Source: CMS HCPCS Level II quarterly file, October 2026. Reference only – check payer policy before billing.