C5271 – Application of low cost skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; first 25 sq cm or less wound surface area
HCPCS Level II code · C codes: Outpatient PPS (Hospital Outpatient)
HCPCS codeC5271
- Long description
- Application of low cost skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; first 25 sq cm or less wound surface area
- Short description
- Low cost skin substitute app
- Pricing indicator
53Statute- Medicare coverage
DSpecial coverage instructions apply- BETOS category
P5AAmbulatory procedures - skin- Added
- January 1, 2014
- Last change
- January 1, 2026 – No change
- Termination date
- December 31, 2025
Frequently asked questions
What is HCPCS code C5271?
C5271 is a HCPCS Level II code for application of low cost skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; first 25 sq cm or less wound surface area. It was discontinued on December 31, 2025.
Does Medicare cover C5271?
The HCPCS file lists coverage code D: Special coverage instructions apply. Coverage and payment also depend on local coverage determinations and the patient’s plan.
Nearby C codes
- C2640 – Brachytherapy source, stranded, palladium-103, per source
- C2641 – Brachytherapy source, non-stranded, palladium-103, per source
- C2642 – Brachytherapy source, stranded, cesium-131, per source
- C2643 – Brachytherapy source, non-stranded, cesium-131, per source
- C2644 – Brachytherapy source, cesium-131 chloride solution, per millicurie
- C2645 – Brachytherapy planar source, palladium-103, per square millimeter
- C2698 – Brachytherapy source, stranded, not otherwise specified, per source
- C2699 – Brachytherapy source, non-stranded, not otherwise specified, per source
- C5272 – Application of low cost skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; each additional 25 sq cm wound surface area, or part thereof (list separately in addition to code for primary procedure)
- C5273 – Application of low cost skin substitute graft to trunk, arms, legs, total wound surface area greater than or equal to 100 sq cm; first 100 sq cm wound surface area, or 1% of body area of infants and children
- C5274 – Application of low cost skin substitute graft to trunk, arms, legs, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (list separately in addition to code for primary procedure)
- C5275 – Application of low cost skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area up to 100 sq cm; first 25 sq cm or less wound surface area
- C5276 – Application of low cost skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area up to 100 sq cm; each additional 25 sq cm wound surface area, or part thereof (list separately in addition to code for primary procedure)
- C5277 – Application of low cost skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; first 100 sq cm wound surface area, or 1% of body area of infants and children
- C5278 – Application of low cost skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (list separately in addition to code for primary procedure)
- C7500 – Debridement, bone including epidermis, dermis, subcutaneous tissue, muscle and/or fascia, if performed, first 20 sq cm or less with manual preparation and insertion of deep (e.g., subfacial) drug-delivery device(s)
Source: CMS HCPCS Level II quarterly file, October 2026. Reference only – check payer policy before billing.