Z88 – Allergy status to drugs, medicaments and biological substances

ICD-10-CM 2027 diagnosis code · Persons with potential health hazards related to family and personal history and certain conditions influencing health status

Non-billable header

ICD-10-CM code Z88

Code: Z88 (claims format: Z88)
Description: Allergy status to drugs, medicaments and biological substances
Short description: Allergy status to drug/meds/biol subst
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 21. Factors influencing health status and contact with health services (Z00-Z99)
Block: Z77-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status

Billable codes under Z88

Z88 is a header code and cannot be used on claims. Choose the most specific code:

Z88.0 – Allergy status to penicillinBillable
Z88.1 – Allergy status to other antibiotic agentsBillable
Z88.2 – Allergy status to sulfonamidesBillable
Z88.3 – Allergy status to other anti-infective agentsBillable
Z88.4 – Allergy status to anesthetic agentBillable
Z88.5 – Allergy status to narcotic agentBillable
Z88.6 – Allergy status to analgesic agentBillable
Z88.7 – Allergy status to serum and vaccineBillable
Z88.8 – Allergy status to other drugs, medicaments and biological substancesBillable
Z88.9 – Allergy status to unspecified drugs, medicaments and biological substancesBillable

Notes for Z88

Excludes2 (not included here):

Allergy status, other than to drugs and biological substances (Z91.0-)

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

Block Z77-Z99

Code also:

any follow-up examination (Z08-Z09)

Frequently asked questions

What is ICD-10 code Z88?

Z88 is the ICD-10-CM code for allergy status to drugs, medicaments and biological substances, in the block Z77-Z99 (Persons with potential health hazards related to family and personal history and certain conditions influencing health status).

Is Z88 a billable code?

No. Z88 is a header code with more specific child codes; report one of the billable codes listed above.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.