T80.52 – Anaphylactic reaction due to vaccination

ICD-10-CM 2027 diagnosis code · Complications of surgical and medical care, not elsewhere classified

Non-billable header

ICD-10-CM code T80.52

Code: T80.52 (claims format: T8052)
Description: Anaphylactic reaction due to vaccination
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 19. Injury, poisoning and certain other consequences of external causes (S00-T88)
Block: T80-T88 Complications of surgical and medical care, not elsewhere classified
Parent codes: T80 › T80.5

Billable codes under T80.52

T80.52 is a header code and cannot be used on claims. Choose the most specific code:

7th character values

Codes in this category need a 7th character to describe the encounter or episode of care (use placeholder X for empty positions).

Character	Meaning
`A`	initial encounter
`D`	subsequent encounter
`S`	sequela

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

T80 – Complications following infusion, transfusion and therapeutic injection

Includes:

complications following perfusion

Excludes2 (not included here):

bone marrow transplant rejection (T86.01)
febrile nonhemolytic transfusion reaction (R50.84)
fluid overload due to transfusion (E87.71)
posttransfusion purpura (D69.51)
transfusion associated circulatory overload (TACO) (E87.71)
transfusion (red blood cell) associated hemochromatosis (E83.111)
transfusion related acute lung injury (TRALI) (J95.84)

7th character note:

The appropriate 7th character is to be added to each code from category T80

T80.5 – Anaphylactic reaction due to serum

Applicable to:

Allergic shock due to serum
Anaphylactic shock due to serum
Anaphylactoid reaction due to serum
Anaphylaxis due to serum

Excludes1 (not coded here):

ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
allergic reaction or shock NOS (T78.2)
anaphylactic reaction or shock NOS (T78.2)
anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
other serum reaction (T80.6-)

Block T80-T88

Excludes2 (not included here):

any encounters with medical care for postprocedural conditions in which no complications are present, such as:
artificial opening status (Z93.-)
closure of external stoma (Z43.-)
fitting and adjustment of external prosthetic device (Z44.-)
burns and corrosions from local applications and irradiation (T20-T32)
complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
mechanical complication of respirator [ventilator] (J95.850)
poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
postprocedural fever (R50.82)
specified complications classified elsewhere, such as:
cerebrospinal fluid leak from spinal puncture (G97.0)
colostomy malfunction (K94.0-)
disorders of fluid and electrolyte imbalance (E86-E87)
functional disturbances following cardiac surgery (I97.0-I97.1)
intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
ostomy complications (J95.0-, K94.-, N99.5-)
postgastric surgery syndromes (K91.1)
postlaminectomy syndrome NEC (M96.1)
postmastectomy lymphedema syndrome (I97.2)
postsurgical blind-loop syndrome (K91.2)
ventilator associated pneumonia (J95.851)

Use additional code:

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
code(s) to identify the specified condition resulting from the complication
code to identify devices involved and details of circumstances (Y62-Y82)

Index terms for T80.52

Entries in the ICD-10-CM alphabetic index that lead to this code:

Related codes in T80.5

Frequently asked questions

What is ICD-10 code T80.52?

T80.52 is the ICD-10-CM code for anaphylactic reaction due to vaccination, in the block T80-T88 (Complications of surgical and medical care, not elsewhere classified).

Is T80.52 a billable code?

No. T80.52 is a header code with more specific child codes; report one of the billable codes listed above.

What category does T80.52 belong to?

It belongs to category T80 – Complications following infusion, transfusion and therapeutic injection.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.