T43.221 – Poisoning by selective serotonin reuptake inhibitors, accidental (unintentional)

ICD-10-CM 2027 diagnosis code · Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances

Non-billable header

ICD-10-CM code T43.221

Code: T43.221 (claims format: T43221)
Description: Poisoning by selective serotonin reuptake inhibitors, accidental (unintentional)
Short description: Poisoning by selective serotonin reuptake inhibitors, acc
Billable: No – use a more specific code below
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 19. Injury, poisoning and certain other consequences of external causes (S00-T88)
Block: T36-T50 Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances
Parent codes: T43 › T43.2 › T43.22

Billable codes under T43.221

T43.221 is a header code and cannot be used on claims. Choose the most specific code:

7th character values

Codes in this category need a 7th character to describe the encounter or episode of care.

Character	Meaning
`A`	initial encounter
`D`	subsequent encounter
`S`	sequela

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

T43 – Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified

Excludes2 (not included here):

appetite depressants (T50.5-)
barbiturates (T42.3-)
benzodiazepines (T42.4-)
drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.- -F19.-)
methaqualone (T42.6-)
psychodysleptics [hallucinogens] (T40.7-T40.9-)

7th character note:

The appropriate 7th character is to be added to each code from category T43

T43.22 – Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors

Applicable to:

Poisoning by, adverse effect of and underdosing of SSRI antidepressants

Block T36-T50

Includes:

adverse effect of correct substance properly administered
poisoning by overdose of substance
poisoning by wrong substance given or taken in error
underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1 (not coded here):

toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2 (not included here):

abuse and dependence of psychoactive substances (F10-F19)
abuse of non-dependence-producing substances (F55.-)
immunodeficiency due to drugs (D84.821)
drug reaction and poisoning affecting newborn (P00-P96)
pathological drug intoxication (inebriation) (F10-F19)

Code first:

, for adverse effects, the nature of the adverse effect, such as:
adverse effect NOS (T88.7)
aspirin gastritis (K29.-)
blood disorders (D56-D76)
contact dermatitis (L23-L25)
dermatitis due to substances taken internally (L27.-)
nephropathy (N14.0-N14.2)

Use additional code:

code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
underdosing of medication regimen (Z91.12-, Z91.13-)

Notes:

The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.

Related codes in T43.22

Frequently asked questions

What is ICD-10 code T43.221?

T43.221 is the ICD-10-CM code for poisoning by selective serotonin reuptake inhibitors, accidental (unintentional), in the block T36-T50 (Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances).

Is T43.221 a billable code?

No. T43.221 is a header code with more specific child codes; report one of the billable codes listed above.

What category does T43.221 belong to?

It belongs to category T43 – Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.