E34.321 – Primary insulin-like growth factor-1 (IGF-1) deficiency
ICD-10-CM 2027 diagnosis code · Disorders of other endocrine glands
ICD-10-CM code
E34.321
- Code
E34.321(claims format:E34321)- Description
- Primary insulin-like growth factor-1 (IGF-1) deficiency
- Billable
- Yes – valid for HIPAA-covered transactions
- Valid for
- Dates of service October 1, 2026 – September 30, 2027 (FY2027)
- Chapter
- 4. Endocrine, nutritional and metabolic diseases (E00-E89)
- Block
- E20-E35 Disorders of other endocrine glands
- Parent codes
- E34 › E34.3 › E34.32
Notes for E34.321
Applicable to:
- Acid-labile subunit gene (IGFALS) defect
- Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Growth hormone insensitivity syndrome (GHIS)
- Insulin-like growth factor 1 gene (IGF1) defect
- Laron type short stature
- Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
- Signal transducer and activator of transcription 5B gene (STAT5b) defect
Notes inherited from parent codes
Instructional notes at a category or block level apply to every code below it.
E34 – Other endocrine disorders
Excludes1 (not coded here):
- pseudohypoparathyroidism (E20.1)
E34.3 – Short stature due to endocrine disorder
Excludes1 (not coded here):
- achondroplastic short stature (Q77.4)
- hypochondroplastic short stature (Q77.4)
- nutritional short stature (E45)
- pituitary short stature (E23.0)
- progeria (E34.8)
- renal short stature (N25.0)
- Russell-Silver syndrome (Q87.19)
- short-limbed stature with immunodeficiency (D82.2)
- short stature (child) (R62.52)
- short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
- short stature NOS (R62.52)
Block E20-E35
Index terms for E34.321
Entries in the ICD-10-CM alphabetic index that lead to this code:
- Dwarfism, Laron-type
- Short, shortening, shortness, stature, Laron-type
- Short, shortening, shortness, stature, due to, genetic causes, growth hormone gene 1
- Short, shortening, shortness, stature, due to, genetic causes, acid-labile subunit gene
- Short, shortening, shortness, stature, due to, genetic causes, insulin-like growth factor 1 gene
- Short, shortening, shortness, stature, due to, genetic causes, primary insulin-like growth factor-1
- Short, shortening, shortness, stature, due to, genetic causes, growth hormone insensitivity syndrome
- Short, shortening, shortness, stature, due to, genetic causes, severe primary insulin-like growth factor-1 deficiency
- Short, shortening, shortness, stature, due to, genetic causes, signal transducer and activator of transcription 5B gene
Related codes in E34.32
Frequently asked questions
What is ICD-10 code E34.321?
E34.321 is the ICD-10-CM code for primary insulin-like growth factor-1 (IGF-1) deficiency, in the block E20-E35 (Disorders of other endocrine glands).
Is E34.321 a billable code?
Yes. E34.321 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.
What category does E34.321 belong to?
It belongs to category E34 – Other endocrine disorders.
Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.