D46.21 – Refractory anemia with excess of blasts 1

ICD-10-CM 2027 diagnosis code · Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

Billable code

ICD-10-CM code D46.21

Code: D46.21 (claims format: D4621)
Description: Refractory anemia with excess of blasts 1
Billable: Yes – valid for HIPAA-covered transactions
Valid for: Dates of service October 1, 2026 – September 30, 2027 (FY2027)
Chapter: 2. Neoplasms (C00-D49)
Block: D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
Parent codes: D46 › D46.2

Notes for D46.21

Applicable to:

RAEB 1

Notes inherited from parent codes

Instructional notes at a category or block level apply to every code below it.

D46 – Myelodysplastic syndromes

Excludes2 (not included here):

drug-induced aplastic anemia (D61.1)

Use additional code:

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Block D37-D48

Excludes1 (not coded here):

neoplasms of unspecified behavior (D49.-)

Notes:

Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.

Index terms for D46.21

Entries in the ICD-10-CM alphabetic index that lead to this code:

Anemia, refractory, with, excess of blasts, 1

Related codes in D46.2

Frequently asked questions

What is ICD-10 code D46.21?

D46.21 is the ICD-10-CM code for refractory anemia with excess of blasts 1, in the block D37-D48 (Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes).

Is D46.21 a billable code?

Yes. D46.21 is a billable/specific code that can be used to indicate a diagnosis for reimbursement purposes.

What category does D46.21 belong to?

It belongs to category D46 – Myelodysplastic syndromes.

Source: CDC/NCHS ICD-10-CM FY2027 code files, tabular list and index. Reference only – code assignment must follow the official ICD-10-CM guidelines and documentation in the medical record.