J0221 – Injection, alglucosidase alfa, (lumizyme), 10 mg
HCPCS Level II code · J codes: Drugs Administered Other Than Oral Method
HCPCS codeJ0221
- Long description
- Injection, alglucosidase alfa, (lumizyme), 10 mg
- Short description
- Lumizyme injection
- Pricing indicator
51Drugs- Medicare coverage
CCarrier judgment – coverage decided by the Medicare contractor- BETOS category
O1EOther drugs- ASC
- Approved for ambulatory surgical centers
- Added
- January 1, 2012
- Last change
- January 1, 2012 – No change
Frequently asked questions
What is HCPCS code J0221?
J0221 is a HCPCS Level II code for injection, alglucosidase alfa, (lumizyme), 10 mg.
Does Medicare cover J0221?
The HCPCS file lists coverage code C: Carrier judgment – coverage decided by the Medicare contractor. Coverage and payment also depend on local coverage determinations and the patient’s plan.
Nearby J codes
- J0210 – Injection, methyldopate hcl, up to 250 mg
- J0211 – Injection, sodium nitrite 3 mg and sodium thiosulfate 125 mg (nithiodote)
- J0215 – Injection, alefacept, 0.5 mg
- J0216 – Injection, alfentanil hydrochloride, 500 micrograms
- J0217 – Injection, velmanase alfa-tycv, 1 mg
- J0218 – Injection, olipudase alfa-rpcp, 1 mg
- J0219 – Injection, avalglucosidase alfa-ngpt, 4 mg
- J0220 – Injection, alglucosidase alfa, 10 mg, not otherwise specified
- J0222 – Injection, patisiran, 0.1 mg
- J0223 – Injection, givosiran, 0.5 mg
- J0224 – Injection, lumasiran, 0.5 mg
- J0225 – Injection, vutrisiran, 1 mg
- J0248 – Injection, remdesivir, 1 mg
- J0256 – Injection, alpha 1 proteinase inhibitor (human), not otherwise specified, 10 mg
- J0257 – Injection, alpha 1 proteinase inhibitor (human), (glassia), 10 mg
- J0270 – Injection, alprostadil, 1.25 mcg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
Source: CMS HCPCS Level II quarterly file, October 2026. Reference only – check payer policy before billing.